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中文名稱：兔抗AKT1/AKT2/AKT3 (phospho-Tyr315/316/312)多克隆抗體
英文名稱： Anti-AKT1/AKT2/AKT3 (phospho-Tyr315/316/312) rabbit polyclonal antibody
相關(guān)類別： 一抗
儲 存： 冷凍（-20℃） 避光
宿 主： Rabbit
抗 原： AKT1/AKT2/AKT3 (phospho-Tyr315/316/312)
反應(yīng)種屬： Human, Mouse, Rat
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. /General protein kinase capable of phosphorylating several known proteins. IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent. |
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Applications: |
WB, IHC, IF |
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Name of antibody: |
AKT1/AKT2/AKT3 (phospho-Tyr315/316/312) |
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Immunogen: |
Synthetic peptide of human AKT1/AKT2/AKT3 (phospho-Tyr315/316/312) |
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Full name: |
AKT1/AKT2/AKT3 (phospho-Tyr315/316/312) |
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SwissProt: |
P31749 |
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IHC positive control: |
Human breast carcinoma |
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IHC Recommend dilution: |
50-100 |
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WB Predicted band size: |
60 kDa |
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WB Positive control: |
HepG2 cells treated with EGF |
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WB Recommended dilution: |
500-1000 |
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IF Positive control: |
Hela cells |
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IF Recommended dilution |
100-200 |
