購(gòu)物車(chē)
幫助
021-54845833/15800441009
中文名稱(chēng)：兔抗BRCA1多克隆抗體
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Background: |
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
BRCA1 |
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Immunogen: |
Fusion protein of human BRCA1 |
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Full name: |
breast cancer 1, early onset |
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Synonyms： |
IRIS; PSCP; BRCAI; BRCC1; PNCA4; RNF53; BROVCA1; PPP1R53 |
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SwissProt: |
P38398 |
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ELISA Recommended dilution: |
1000-5000 |
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IHC positive control: |
Human liver cancer and human cervical cancer |
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IHC Recommend dilution: |
50-200 |
