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021-54845833/15800441009
中文名稱 ： 兔抗PTAFR多克隆抗體
英文名稱 ： Anti-PTAFR rabbit polyclonal antibody
別 名： PAFR
相關(guān)類別： 一抗
儲 存： 冷凍（-20℃）
宿 主： Rabbit
抗 原： PTAFR
反應(yīng)種屬： Human
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
PTAFR |
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Immunogen: |
Synthetic peptide of human PTAFR |
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Full name: |
Platelet-activating factor receptor |
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Synonyms: |
PAFR |
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SwissProt: |
P25105 |
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IHC positive control: |
Human gastric cancer |
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IHC Recommend dilution: |
25-100 |
