購物車
幫助
021-54845833/15800441009
中文名稱：GSKIP抗原（重組蛋白）
英文名稱： GSKIP Antigen (Recombinant Protein)
別 名： HSPC210; C14orf129
儲(chǔ) 存： 冷凍（-20℃）
相關(guān)類別： 抗原
概 述：
|
Fusion protein corresponding to a region derived from 1-139 amino acids of human GSKIP |
|
Full name: |
GSK3B interacting protein |
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Synonyms: |
HSPC210; C14orf129 |
|
Swissprot: |
Q9P0R6 |
|
Gene Accession: |
BC004818 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene. |
