購物車
幫助
021-54845833/15800441009
中文名稱：PPM1D 抗原（重組蛋白）
別 名： protein phosphatase, Mg2+/Mn2+ dependent 1D; WIP1; PP2C-DELTA
儲 存： 冷凍（-20℃）
相關(guān)類別： 抗原
概 述：
|
Fusion protein corresponding to a region derived from 459-605 amino acids of human PPM1D |
|
Full name: |
protein phosphatase, Mg2+/Mn2+ dependent 1D |
|
Synonyms: |
WIP1; PP2C-DELTA |
|
Swissprot: |
O15297 |
|
Gene Accession: |
BC033893 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. |
