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中文名稱： BCAS2抗原（重組蛋白）
英文名稱： BCAS2 Antigen (Recombinant Protein)
儲 存： 冷凍（-20℃）
相關(guān)類別： 抗原
概 述
|
Full name: |
breast carcinoma amplified sequence 2 |
|
Synonyms: |
DAM1; SPF27; Snt309 |
|
Swissprot: |
O75934 |
|
Gene Accession: |
BC005285 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
BCAS2 (breast carcinoma amplified sequence 2), also designated DAM1 (DNA amplified in mammary carcinoma 1 protein) or spliceosome-associated SPF 27, is a ubiquitously expressed nuclear protein that was originally identified as being overexpressed in various breast cancer cell lines. BCAS2 is now known to be a component of the spliceosome, participating in the removal of introns from mRNA precursors. BCAS2 specifically interacts (in a ligand-independent manner) with TR∫ (thyroid hormone receptor beta), ER? (estrogen receptor alpha), ER∫, PR (progesterone receptor), and PPAR? (Peroxisome proliferator-activated receptor gamma). BCAS2 functions as an ER coactivator and is capable of enhancing ER-mediated transcription. This suggests that BCAS2 is involved in the development of breast cancer. |
