購物車
幫助
021-54845833/15800441009
中文名稱：CASP3抗原（重組蛋白）
英文名稱：CASP3 Antigen (Recombinant Protein)
儲(chǔ) 存：冷凍（-20℃）
相關(guān)類別：抗原
概述
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Fusion protein corresponding to N terminal 269 amino acids of human CASP3 |
技術(shù)規(guī)格
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Full name: |
caspase 3, apoptosis-related cysteine peptidase |
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Synonyms: |
CPP32, SCA-1, CPP32B |
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Swissprot: |
P42574 |
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Gene Accession: |
BC016926 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. |
