購物車
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021-54845833/15800441009
中文名稱：ARRB1抗原（重組蛋白）
英文名稱：ARRB1 Antigen (Recombinant Protein)
儲 存：冷凍（-20℃）
相關類別：抗原
概述
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Fusion protein corresponding to a region derived from 46-300 amino acids of human ARRB1 |
技術規(guī)格
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Full name: |
arrestin, beta 1 |
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Synonyms: |
ARB1; ARR1 |
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Swissprot: |
P49407 |
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Gene Accession: |
BC003636 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. |
