購(gòu)物車
幫助
021-54845833/15800441009
中文名稱：小鼠抗IKZF1(C-term)單克隆抗體
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Background: |
This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). |
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Applications: |
WB, IP |
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Name of antibody: |
IKZF1(C-term) |
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Immunogen: |
Fusion protein of human IKZF1 |
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Full name: |
IKAROS family zinc finger 1 |
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Synonyms: |
IK1; LYF1; LyF-1; CVID13; IKAROS; PPP1R92; PRO0758; ZNFN1A1; Hs.54452 |
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SwissProt: |
Q13422 |
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WB Predicted band size: |
58 kDa |
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WB Positive control: |
Ramos and Jurkat cell lysates |
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WB Recommended dilution: |
1000-5000 |
