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中文名稱： C4BPB 抗原（重組蛋白）
英文名稱： C4BPB Antigen (Recombinant Protein)
別 名： complement component 4 binding protein beta; C4BP
儲 存： 冷凍（-20℃）
相關(guān)類別：抗原
技術(shù)規(guī)格：
Full name:
complement component 4 binding protein beta
Synonyms:
C4BP
Swissprot:
P20851
Gene Accession:
BC005378
Purity:
>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:
Escherichia coli
Tags:
His tag C-Terminus, GST tag N-Terminus
Background:
This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.
