購(gòu)物車
幫助
021-54845833/15800441009
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Background: |
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
TEAD2 |
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Immunogen: |
Fusion protein of human TEAD2 |
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Full name: |
TEA domain transcription factor 2 |
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Synonyms: |
ETF; TEF4; TEF-4; TEAD-2 |
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SwissProt: |
Q15562 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human gastric cancer |
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IHC Recommend dilution: |
40-200 |
