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021-54845833/15800441009
中文名稱： 兔抗RRP8多克隆抗體
英文名稱： Anti-RRP8 rabbit polyclonal antibody
別 名： ribosomal RNA processing 8; NML; KIAA0409
相關(guān)類別： 一抗
儲 存： 冷凍（-20℃）
宿 主： Rabbit
抗 原： RRP8
反應(yīng)種屬： Human, Mouse, Rat
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
Background:
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Applications:
ELISA, WB, IHC
Name of antibody:
RRP8
Immunogen:
Fusion protein of human RRP8
Full name:
ribosomal RNA processing 8
Synonyms:
NML; KIAA0409
SwissProt:
O43159
ELISA Recommended dilution:
5000-10000
IHC positive control:
Human esophagus cancer and Human breast cancer
IHC Recommend dilution:
50-300
WB Predicted band size:
51 kDa
WB Positive control:
Human cerebella tissue, K562 cell lysates
WB Recommended dilution:
500-2000
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