購物車
幫助
021-54845833/15800441009
概 述
|
Full name: |
NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase |
|
Synonyms: |
NSE2; MMS21; ZMIZ7; C8orf36 |
|
Swissprot: |
Q96MF7 |
|
Gene Accession: |
BC032797 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
NSMCE2 is the E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. NSMCE2 acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair. |
