購物車
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中文名稱： 兔抗MC1R多克隆抗體
英文名稱： Anti-MC1R rabbit polyclonal antibody
別 名： CMM5, MSH-R, SHEP2
相關(guān)類別： 一抗
儲 存： 冷凍（-20℃）
宿 主： Rabbit
抗 原： MC1R
反應(yīng)種屬： Human, Mouse
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
MC1R |
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Immunogen: |
Synthetic peptide of human MC1R |
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Full name: |
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) |
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Synonyms: |
CMM5, MSH-R, SHEP2 |
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SwissProt: |
Q01726 |
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IHC positive control: |
Human colon cancer and human gastric cancer |
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IHC Recommend dilution: |
50-200 |
