購物車
幫助
021-54845833/15800441009
中文名稱： IKBIP 抗原（重組蛋白）
英文名稱： IKBIP Antigen (Recombinant Protein)
別 名： IKBKB interacting protein; IKIP
儲(chǔ) 存： 冷凍（-20℃）
相關(guān)類別： 抗原
概述
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Fusion protein corresponding to a region derived from 71-350 amino acids of human IKBIP |
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Full name: |
IKBKB interacting protein |
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Synonyms: |
IKIP |
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Swissprot: |
Q70UQ0 |
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Gene Accession: |
BC058933 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
IKIP (Inhibitor of nuclear factor kappa-B kinase-interacting protein, IKK-interacting protein) is a single-pass membrane protein that shares a common promoter with APAF1. APAF1 and IKIP are both induced by X irradiation, however, the two gene products are transcribed in different directions. The IKIP gene is believed to be a target for p53 as expression of IKIP has been shown to promote apoptosis. IKIP has four known isoforms, three of which are found traversing the endoplasmic reticulum membrane. IKIP isoform 4 has a deletion of the transmembrane region which leads to a homogenous distribution of the protein within the cell. The IKIP gene products are expressed in vascular endothelial cells, while the isoform 4 has also been detected in lung, kidney, spleen, thymus and skeletal muscle. |
