購物車
幫助
021-54845833/15800441009
|
Fusion protein corresponding to a region derived from 530-847 amino acids of human STAT6 |
|
Full name: |
signal transducer and activator of transcription 6, interleukin-4 induced |
|
Synonyms: |
STAT6B; STAT6C; D12S1644; IL-4-STAT |
|
Swissprot: |
P42226 |
|
Gene Accession: |
BC075852 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants. |
