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    • NFKBIE抗原(重組蛋白)

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      價(jià)格:
      • 品牌 : 通蔚生物
      • 目錄號(hào) : TW17760
      • 應(yīng)用 : 僅供科研使用
      • 貨期 : 現(xiàn)貨
      • 規(guī)格 :1mg/100ug
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    中文名稱(chēng):NFKBIE抗原(重組蛋白)

    英文名稱(chēng): NFKBIE Antigen (Recombinant Protein)

    儲(chǔ)       存: 冷凍(-20℃)

    相關(guān)類(lèi)別: 抗原

    概述

    Fusion protein corresponding to a region derived from 63-423 amino acids of human NFKBIE

    技術(shù)規(guī)格

    Full name:

    Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon

    Synonyms:

    IKBE

    Swissprot:

    O00221

    Gene Accession:

    BC011676

    Purity:

    >85%, as determined by Coomassie blue stained SDS-PAGE

    Expression system:

    Escherichia coli

    Tags:

    His tag C-Terminus, GST tag N-Terminus

    Background:

    The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. NFKBIE protein expression is up-regulated following NF-κB activation and during myelopoiesis. NFKBIE is able to inhibit NF-κB-directed transactivation via cytoplasmic retention of REL proteins. NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NF-κB transcription factor complex. The NF-κB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm.

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