購(gòu)物車(chē)
幫助
021-54845833/15800441009
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Background: |
Dynactin is a multisubunit complex and a required cofactor for most, or all, of the cellular processes powered by the microtubule-based motor cytoplasmic dynein . Dynactin contains a short actin-related protein 1 (Arp1) filament with capZ at the barbed end and p62 at the pointed end . The p62 subunit is an integral component of 20 S dynactin with a highly conserved cysteine-rich motif that interacts directly with Arp1. Dynactin p62 has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin . In addition, Dynactin p62 is distributed in the nucleus at very high expression levels . Due to the structural composition of dynactin, the p62 subunit is implicated in Arp1 pointed-end binding and in linking dynein and dynactin to the cortical cytoskeleton. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
DCTN4 |
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Immunogen: |
Fusion protein of human DCTN4 |
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Full name: |
dynactin 4 (p62) |
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Synonyms： |
P62; DYN4 |
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SwissProt: |
Q9UJW0 |
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ELISA Recommended dilution: |
2000-10000 |
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IHC positive control: |
Human ovarian cancer and human cervical cancer |
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IHC Recommend dilution: |
100-300 |
