購物車
幫助
021-54845833/15800441009
中文名稱： 兔抗MALT1多克隆抗體
英文名稱： Anti-MALT1 rabbit polyclonal antibody
別 名： DKFZp434L132; MLT; MLT1
相關(guān)類別：一抗
儲 存： 冷凍（-20℃） 避光
宿 主： Rabbit
抗 原： MALT1
反應(yīng)種屬：Human, Mouse, Rat
標(biāo) 記 物：Unconjugate
克隆類型：rabbit polyclonal
技術(shù)規(guī)格
Background:
Mucosa-associated lymphoid tissue translocation gene 1 (MALT1) is a paracaspase that is a critical mediator of T-cell receptor activation of NF-κB and may contribute to the progression of MALT lymphomas. It contains two immunoglobulin-like domains, an amino-terminal death domain and a carboxy-terminal caspase-like domain. Association of MALT1 with Bcl-10 and CARD11/Carma1 leads to activation of IKK and subsequent stimulation of NF-κB, resulting in increased proliferation and inhibition of apoptosis. A common translocation in MALT B-cell non-Hodgkin lymphomas t(11;18)(q21;q21) results in the fusion of the amino terminus of API2 (c-IAP2), a member of the inhibitor of apoptosis protein family, to the carboxy terminus of MALT1. The API2-MALT1 fusion protein likely leads to deregulation of NF-κB, contributing to increased oncogenic potential.
Applications:
WB
Name of antibody:
MALT1
Immunogen:
Fusion protein of human MALT1
Full name:
mucosa associated lymphoid tissue lymphoma translocation gene 1
Synonyms：
DKFZp434L132; MLT; MLT1
SwissProt:
Q9UDY8
WB Predicted band size:
92 kDa
WB Positive control:
Jurkat and K562 cells, bone marrow tissue
WB Recommended dilution:
500-2000
