購(gòu)物車(chē)
幫助
021-54845833/15800441009
中文名稱(chēng)： DENND1A 抗原（重組蛋白）
相關(guān)類(lèi)別： 抗原
概 述
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Full name: |
DENN domain containing 1A |
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Synonyms: |
FAM31A; KIAA1608 |
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Swissprot: |
Q8TEH3 |
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Gene Accession: |
BC039703 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]). |
