購物車
幫助
021-54845833/15800441009
中文名稱：ACVR2A 抗原（重組蛋白）
英文名稱： ACVR2A Antigen (Recombinant Protein)
別 名： Activin A receptor, type IIA; ACVR2; ACTRII
儲 存： 冷凍（-20℃）
相關(guān)類別： 抗原
概 述：
|
Fusion protein corresponding to a region derived from 195-485 amino acids of human ACVR2A |
|
Full name: |
Activin A receptor, type IIA |
|
Synonyms: |
ACVR2; ACTRII |
|
Swissprot: |
P27037 |
|
Gene Accession: |
BC069707 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. |
