購(gòu)物車(chē)
幫助
021-54845833/15800441009
技術(shù)規(guī)格
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Background: |
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. |
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Applications: |
WB, IHC, IF, FC |
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Name of antibody: |
SETD7 |
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Immunogen: |
Fusion protein of human SETD7 |
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Full name: |
SET domain containing (lysine methyltransferase) 7 (SETD7) |
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Synonyms: |
KMT7; SET7; SET7/9; SET9 |
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SwissProt: |
Q8WTS6 |
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IHC positive control: |
adenocarcinoma of human endometrium tissue and carcinoma of human bladder tissue |
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IHC Recommend dilution: |
30-150 |
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WB Predicted band size: |
41 kDa |
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WB Positive control: |
Hela, SVT2, A549, COS7, Jurkat, MDCK, PC12, MCF-7 cell lysates |
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WB Recommended dilution: |
500-2000 |
