購物車
幫助
021-54845833/15800441009
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Background: |
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq]. |
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Applications: |
WB, IF |
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Name of antibody: |
RUNX1T1 |
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Immunogen: |
Fusion protein of human RUNX1T1 |
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Full name: |
runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (RUNX1T1), transcript variant 3 |
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Synonyms: |
CDR; ETO; MTG8; AML1T1; ZMYND2; CBFA2T1; AML1-MTG8 |
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SwissProt: |
Q06455 |
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WB Predicted band size: |
68 kDa |
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WB Positive control: |
Hela, SVT2, A549, COS7, Jurkat, PC12, MCF-7 cell lysates |
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WB Recommended dilution: |
500-2000 |
