購物車
幫助
021-54845833/15800441009
標 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
|
Background: |
Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227). Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580). Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (PubMed:25092918). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity). Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity). |
|
Applications: |
ELISA, IHC |
|
Name of antibody: |
LYAR |
|
Immunogen: |
Fusion protein of human LYAR |
|
Full name: |
Ly1 antibody reactive |
|
Synonyms: |
ZLYAR; ZC2HC2 |
|
SwissProt: |
Q9NX58 |
|
ELISA Recommended dilution: |
5000-10000 |
|
IHC positive control: |
Human thyroid cancer |
|
IHC Recommend dilution: |
50-200 |
