購(gòu)物車
幫助
021-54845833/15800441009
中文名稱：CCL4抗原（重組蛋白）
英文名稱：CCL4 Antigen (Recombinant Protein)
儲(chǔ) 存：冷凍（-20℃）
相關(guān)類別：抗原
概述
|
Fusion protein corresponding to a region derived from 24-92 amino acids of human CCL4 |
技術(shù)規(guī)格
|
Full name: |
chemokine (C-C motif) ligand 4 |
|
Synonyms: |
ACT2; G-26; HC21; LAG1; LAG-1; MIP1B; SCYA2; SCYA4; MIP1B1; AT744.1; MIP-1-beta |
|
Swissprot: |
P13236 |
|
Gene Accession: |
BC104226 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. |
