購(gòu)物車
幫助
021-54845833/15800441009
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Background: |
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
TNFSF11 |
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Immunogen: |
Synthetic peptide corresponding to a region derived from 304-317 amino acids of human TNFSF11 |
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Full name: |
tumor necrosis factor superfamily member 11 |
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Synonyms: |
ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TNLG6B; TRANCE; hRANKL2 |
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SwissProt: |
O14788 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC Positive control: |
Human esophagus cancer;Human brain |
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IHC Recommended dilution: |
20-100 |
