購(gòu)物車(chē)
幫助
021-54845833/15800441009
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Background: |
The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans. |
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Applications: |
WB, IF |
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Name of antibody: |
GRID2 |
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Immunogen: |
Synthesized peptide derived from internal of human GRID2. |
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Full name: |
glutamate receptor, ionotropic, delta 2 |
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Synonyms： |
GluD2 |
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SwissProt: |
O43424 |
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WB Predicted band size: |
113 kDa |
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WB Positive control: |
NIH/3T3 cells lysate |
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WB Recommended dilution: |
500-3000 |
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IF positive control: |
Huvec cells |
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IF Recommend dilution: |
100-500 |
