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中文名稱(chēng)： 兔抗PRKCB (Phospho-Thr641)多克隆抗體
英文名稱(chēng)： Anti-PRKCB (Phospho-Thr641) rabbit polyclonal antibody
別 名： PKCB; PRKCB1; PRKCB2; PKC-beta
相關(guān)類(lèi)別： 一抗
儲(chǔ) 存： 冷凍（-20℃） 避光
宿 主： Rabbit
抗 原： PRKCB (Phospho-Thr641)
反應(yīng)種屬： Human, Mouse, Rat
標(biāo) 記 物： Unconjugate
克隆類(lèi)型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell suvival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652', leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. Also involved in triglyceride homeostasis. Serves as the receptor for phorbol esters, a class of tumor promoters. |
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Applications: |
WB, IHC, IF |
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Name of antibody: |
PRKCB (Phospho-Thr641) |
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Immunogen: |
Synthetic peptide of human PRKCB (Phospho-Thr641) |
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Full name: |
protein kinase C, beta (Phospho-Thr641) |
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Synonyms： |
PKCB; PRKCB1; PRKCB2; PKC-beta |
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SwissProt: |
P05771 |
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IHC positive control: |
Human lung carcinoma |
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IHC Recommend dilution: |
50-100 |
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WB Predicted band size: |
82 kDa |
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WB Positive control: |
Jurkat cells untreated or treated with PMA |
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WB Recommended dilution: |
500-1000 |
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IF Positive control: |
MCF7 cells |
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IF Recommended dilution |
100-200 |
