購(gòu)物車
幫助
021-54845833/15800441009
中文名稱： 兔抗PML多克隆抗體
英文名稱： Anti-PML rabbit polyclonal antibody
別 名： MYL; RNF71; PP8675; TRIM19
相關(guān)類別： 一抗
儲(chǔ) 存： 冷凍（-20℃） 避光
宿 主： Rabbit
抗 原： PML
反應(yīng)種屬： Human, Mouse, Rat
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. |
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Applications: |
WB |
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Name of antibody: |
PML |
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Immunogen: |
Fusion protein of human PML |
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Full name: |
promyelocytic leukemia |
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Synonyms： |
MYL; RNF71; PP8675; TRIM19 |
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SwissProt: |
P29590 |
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WB Predicted band size: |
98 kDa |
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WB Positive control: |
HeLa cells |
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WB Recommended dilution: |
500-2000 |
