購(gòu)物車(chē)
幫助
021-54845833/15800441009
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Background: |
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. |
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Applications: |
WB, IHC |
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Name of antibody: |
EIF2AK3(Ab-982) |
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Immunogen: |
Synthesized non-phosphopeptide derived from human PEK/PERK around the phosphorylation site of threonine 982(R-H-T(p)-G-Q). |
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Full name: |
eukaryotic translation initiation factor 2 alpha kinase 3 |
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Synonyms: |
PEK; WRS; PERK |
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SwissProt: |
Q9NZJ5 |
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IHC positive control: |
Human colon carcinoma tissue |
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IHC Recommend dilution: |
50-100 |
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WB Predicted band size: |
125 kDa |
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WB Positive control: |
MCF-7 cells lysate |
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WB Recommended dilution: |
500-3000 |
