購物車
幫助
021-54845833/15800441009
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Background: |
This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. The encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). Alternative splicing results in multiple transcript variants. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
DUX4 |
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Immunogen: |
Synthetic peptide of human DUX4 |
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Full name: |
double homeobox 4 |
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Synonyms: |
DUX4L |
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SwissProt: |
Q9UBX2 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human esophagus cancer;Human thyroid cancer |
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IHC Recommend dilution: |
20-100 |
