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英文名稱： VAC14 Antigen (Recombinant Protein)
別 名： TRX; TAX1BP2; ArPIKfyve
儲 存： 冷凍（-20℃）
相關類別： 抗原
概 述：
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Fusion protein corresponding to a region derived from 583-782 amino acids of human VAC14 |
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Full name: |
VAC14 component of PIKFYVE complex |
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Synonyms: |
TRX; TAX1BP2; ArPIKfyve |
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Swissprot: |
Q08AM6 |
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Gene Accession: |
BC007214 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a scaffold protein that is a component of the PIKfyve protein kinase complex. This complex is responsible for the synthesis of phosphatidylinositol 3,5-bisphosphate, an important component of cellular membranes, from phosphatidylinositol 3-phosphate. Mice lacking a functional copy of this gene exhibit severe neurodegeneration. Mutations in the human gene have been identified in patients with a childhood onset progressive neurological disorder characterized by impaired movement, dystonia, and striatal abnormalities. |
