購(gòu)物車
幫助
021-54845833/15800441009
中文名稱： DAB2抗原（重組蛋白）
英文名稱： DAB2 Antigen (Recombinant Protein)
別 名： DOC2; DOC-2
儲(chǔ) 存： 冷凍（-20℃）
相關(guān)類別： 抗原
概 述：
|
Fusion protein corresponding to a region derived from 209-447 amino acids of human DAB2 |
|
Full name: |
DAB adaptor protein 2 |
|
Synonyms: |
DOC2; DOC-2 |
|
Swissprot: |
P98082 |
|
Gene Accession: |
BC003064 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
