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    • HLA-DMB 抗原(重組蛋白)

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      價(jià)格:
      • 品牌 : 通蔚生物
      • 目錄號(hào) : TW16671
      • 應(yīng)用 : 僅供科研使用
      • 貨期 : 現(xiàn)貨
      • 規(guī)格 :1mg/100ug
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    中文名稱: HLA-DMB 抗原(重組蛋白)

    英文名稱: HLA-DMB Antigen (Recombinant Protein)

    別     名: major histocompatibility complex, class II, DM beta; RING7; D6S221E

    儲(chǔ)     存: 冷凍(-20℃)

    相關(guān)類別: 抗原

    概     述

    Fusion protein corresponding to a region derived from 19-218AA amino acids of human HLA-DMB

    技術(shù)規(guī)格

    Full name:

    major histocompatibility complex, class II, DM beta

    Synonyms:

    RING7; D6S221E

    Swissprot:

    P28068

    Gene Accession:

    BC027175

    Purity:

    >85%, as determined by Coomassie blue stained SDS-PAGE

    Expression system:

    Escherichia coli

    Tags:

    His tag C-Terminus, GST tag N-Terminus

    Background:

    HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.



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