購物車
幫助
021-54845833/15800441009
中文名稱：ACTN4抗原（重組蛋白）
英文名稱： ACTN4 Antigen (Recombinant Protein)
別 名： FSGS; FSGS1; ACTININ-4
儲 存： 冷凍（-20℃）
相關(guān)類別： 抗原
概 述：
|
Fusion protein corresponding to a region derived from 50-269 amino acids of human ACTN4 |
|
Full name: |
actinin, alpha 4 |
|
Synonyms: |
FSGS; FSGS1; ACTININ-4 |
|
Swissprot: |
O43707 |
|
Gene Accession: |
BC005033 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. |
